Sakura Mikan, a girl from Northern of Japan, had a bestfriend named Imai Hotaru. Even though, she doesn't know it, but Hotaru was an alice. After 1-2 years of being friends, Hotaru went to another school where there were people like her, an alice. Mikan, so depressed about Hotaru leaving, went to the school and found at she was an alice as well. She found at that she had a cancellation alice which can cancel alices. Many students thought she somehow tricked the academy into thinking she was an alice. However, Mikan tries her hardest into proving their wrong, lifting up their hopes to be no. 1 and go see their families,etc. She does the best she can to make them friends and let them have confidence in themselves. And for some reason, she somehow changed the academy's students into becoming friends, and even, admirers. This anime is about friendship, love, selflessness, concern for others, and hope.